Science

Ambrotose Complex

Pre-clinical studies suggest that Ambrotose products exert immune system¹ and prebiotic effects, and support gastrointestinal health.* Prebiotic effects, assessed using a state-of-the-art simulation of the human GI tract (SHIME), indicate that Ambrotose products are bifidogenic and may enhance species belonging to Bacteroidetes, a phylum recently associated with body-weight management.²*

In an eight-week, open-label human clinical trial of healthy adults investigating the ability of Advanced Ambrotose powder to impact cellular communication, product intake affected serum glycosylation profiles, significantly increasing levels of disialylated N-linked glycans in human plasma.³*

Three independent placebo-controlled trials of more than 150 healthy adults indicate that intake of Ambrotose powder can also support cognitive health.*

In a randomized, double-blind, 12-week placebo-controlled trial, Ambrotose complex significantly improved memory (as measured by the Rey Auditory-Verbal Learning Test) and decreased anger-hostility, improved mood (as measured by the Profile of Mood States Questionnaire).* Researchers in Mannatech’s laboratory and at academic institutions worldwide are continuing to explore the beneficial health effects of Ambrotose products.

REFERENCES

  1. Ramberg JE, Nelson ED, Sinnott RA. Immunomodulatory dietary polysaccharides: a systematic review of the literature. Nutr J 2010;9:1-60.
  2. Marzorati M, Verhelst A, Luta G et al. In vitro modulation of the human gastrointestinal microbial community by plant-derived polysaccharide-rich dietary supplements. Int J Food Microbiol 2010;139:168-76.
  3. Alavi A, Fraser W, Tarelli E, Bland M, Axford J. An open-label dosing study to evaluate the safety and effects of a dietary plant derived polysaccharide supplement on the N-glycosylation status of serum glycoproteins in healthy subjects. Eur J Clin Nutr 2011;1-9.
  4. Best T, Kemps E, Bryan J. Saccharide effects on cognition and well-being in middle-aged adults: A randomized controlled trial. Dev Neuropsych 2010;35:66-80.