Ambrotose Complex

Pre-clinical studies suggest that Ambrotose products exert immune system¹ and prebiotic effects, and support gastrointestinal health.* Prebiotic effects, assessed using a state-of-the-art simulation of the human GI tract (SHIME), indicate that Ambrotose products are bifidogenic and may enhance species belonging to Bacteroidetes, a phylum recently associated with body-weight management.²*

In an eight-week, open-label human clinical trial of healthy adults investigating the ability of Advanced Ambrotose powder to impact cellular communication, product intake affected serum glycosylation profiles, significantly increasing levels of disialylated N-linked glycans in human plasma.³*

Three independent placebo-controlled trials of more than 150 healthy adults indicate that intake of Ambrotose powder can also support cognitive health.*

In a randomized, double-blind, 12-week placebo-controlled trial, Ambrotose complex significantly improved memory (as measured by the Rey Auditory-Verbal Learning Test) and decreased anger-hostility, improved mood (as measured by the Profile of Mood States Questionnaire).* Researchers in Mannatech’s laboratory and at academic institutions worldwide are continuing to explore the beneficial health effects of Ambrotose products.


  1. Ramberg JE, Nelson ED, Sinnott RA. Immunomodulatory dietary polysaccharides: a systematic review of the literature. Nutr J 2010;9:1-60.
  2. Marzorati M, Verhelst A, Luta G et al. In vitro modulation of the human gastrointestinal microbial community by plant-derived polysaccharide-rich dietary supplements. Int J Food Microbiol 2010;139:168-76.
  3. Alavi A, Fraser W, Tarelli E, Bland M, Axford J. An open-label dosing study to evaluate the safety and effects of a dietary plant derived polysaccharide supplement on the N-glycosylation status of serum glycoproteins in healthy subjects. Eur J Clin Nutr 2011;1-9.
  4. Best T, Kemps E, Bryan J. Saccharide effects on cognition and well-being in middle-aged adults: A randomized controlled trial. Dev Neuropsych 2010;35:66-80.